The One Simple Cause and Cure for Cholinergic Urticaria

Medical Disclaimer: This post is written for informational purposes only. A part of this post discusses some medicine used to treat cholinergic urticaria which only your doctor has the authority to prescribe. Please, before you take any medication, talk to your healthcare supervisor.

Cholinergic urticaria is one of the physical types of urticaria brought on by a physical stimulus. It is clinically characterized by pinpoint-sized, highly pruritic wheals. However, the symptoms diminish quickly, usually within one hour.

Cholinergic urticaria affects both men and women alike, and unlike all the other types of hives, cholinergic urticaria seems to be more common in men than in women.

In comparison to other chronic urticaria types, cholinergic is uncommon and constitutes 5.1% of all chronic urticaria diagnoses.


What causes Cholinergic Urticaria?

CU is typically provoked by stimulation such as heat, prolonged exposure to sun, and emotional stress, which elevates the body’s core temperature and promotes sweating. Although warmth, sunlight or exercise can induce cholinergic urticaria, the actual cause is sweating.


Here is a picture explaining scientifically how cholinergic urticaria occurs.

Don’t worry, in the next few moments we’ll demystify the puzzle. By understanding how cholinergic urticaria is caused, you will understand what can be done to easily get rid of it. Sound fair enough?

There are two types of causes of cholinergic urticaria – one can be called “direct” and the second can be called “peripheral”. The direct cause is sweating hypersensitivity. The peripheral cause takes a longer cycle to end up releasing histamine, which Yassin Madwin mentioned in his book.  The fact of the matter is that this “indirect” cause is another type of urticaria. In this post I’m going to focus on the direct cause: sweating hypersensitivity.


You are aware that your sweat, your hormones, whatever is inside you is there to do a certain job, and that job does not include breaking you out in hives. Thus, you must be doing something wrong, right?

What causes cholinergic urticaria is the stimulation of a chemical called acetylcholine. Acetylcholine is proven to induce both sweating and wheals when injected underneath your skin. And you wouldn’t believe why you break out in cholinergic urticaria: it’s simply because you eat too much salt. Yes, that is the actual cause of your mysterious hives.


Table salt or any other food rich in sodium can trigger and aggravate your cholinergic urticaria. Sodium stimulates acetylcholine release. You can see how this mechanism works here.


How to treat Cholinergic Urticaria.

Cholinergic urticaria can be treated permanently by avoiding salt and sodium-rich foods in general.

Canned foods, sauces, French fries, soup packets – all of these contain way more than the amount of sodium your body needs, which is set at 1500 mg/day.

Reducing or avoiding those types of food is for the long term. Quick treatments for cholinergic urticaria include: Nonsedating H1 receptor antagonists, such as Cetirizine, Danazol,  and beta-blockers, such as Propranolol.

Your doctor may prescribe medication:

  • 4 mg of chlorpheniramine maleate (histidine), 3 times daily.
  • 200 mg of cimetidine (tagadine), 3 times daily.


Antihistamines won’t do much because histamine plays a very minor role in cholinergic urticaria.

The most effective treatment for cholinergic urticaria according to Yassin Madwin is through desensitization using partially purified sweat antigen. You can call it diluting your sweat. This technique succeeded in 5 out of 6 patients (83%). Note that and give it to your dermatologist – he will know what to do next.

Urticaria no more is not a complicated scientific book, but rather a simple and to the point blueprint anyone can follow. In this book you’re going to discover the one link between all types of urticaria, how you can easily get rid of chronic idiopathic urticaria, how hives during pregnancy and menstruation can be very serious, and much more….

How to get rid of stress hives


Can stress cause hives?

Science says yes, and you’re about to discover  how.


In every medical reference, you would see them listing stress as one of the potential causes that can trigger hives or angioedema. Studies of groups of people suffering with different levels of urticaria have proven that stress can worsen hives and that it’s possible to get urticaria induced by stress.

There are some researches that link post-traumatic stress disorder (PTSD), a classic stress-mediated syndrome with urticaria (the medical term for hives or nettle-rash), clearing the possible co-morbidity.

There are many explanations out there: stress-related hives can be the result of an overactive sympathetic nervous system. It’s the same part of the brain that is responsible for “fight or flight” situations. Something else might be the cause.


In theory, we would assume that you are already susceptible to hives and that stress contributes in aggravating the main problem due to hormonal imbalance.

For example, dermatologists insist that masturbation has nothing to do with acne, but trust me – masturbate 3 times a day for 4 hours. The next day, I guarantee that you’ll have a huge pimple on your cheek. Hormonal imbalance can make matters worse. It’s a proven fact.


In his book Urticaria No More, Yassin Madwin stresses that hives cannot be caused by stress, confirming this theory. He shows how hives occur when there is a spike in certain hormones; these hormones need serotonin to work properly (serotonin, AKA the happiness hormone). The more you’re stressed, the more your cortisol rises and your serotonin drops. When this happens, a set of pro-inflammatory agents (basophils) are released into the blood stream, which requires histamine intervention.


You might, in fact, have something different than stress. It might be an autoimmune issue, malfunctioning organs or highly intoxicated body. If you’re sure it’s stress, then let’s proceed…

So, we agreed that stress-induced urticaria is a logical thing; what is not logical is to treat stress with drugs. Drug companies don’t have any single interest in jeopardizing their business in order to tell you the truth. Nobody exactly knows how it happens, but instead, they give you medicine that they are completely aware won’t work for you.

No. Seriously, stress is a mental state. And we treat mental problems with mind treatment, not with supplements. This advice, unfortunately, fails to find and explain the real cause of your stress problem.


The real secret behind stress is the social programming we have gotten since Day 1 of our existence. It’s not your fault. We were raised to go to school and have a job, make a family and have kids and then raise them to do the same. If you fail in one of these steps, you get stressed. You become depressed and anxious whenever you deal with the need for social approval, when you’re about to face a challenge that might change you or change your social status.


What you should really take care of is your wellbeing that is independent from others. You should have a rock solid self-esteem; embrace yourself! If you see that you need a change, do it for yourself (not for them, for you) because you deserve it. When people are just minutes closer to challenging their atheism, you only regret that you didn’t live happily enough or that you didn’t make the choices you wanted for yourself.


I would suggest reading succinct self-improvement blogs or eBooks (see I’m stressed out), not those blogs from the first page of Google that give you generic advice, such as “Stop being anxious!”

Take care, and if you think this post would help someone else, then do me a little favor and share. No pressure.