The One Simple Cause and Cure for Cholinergic Urticaria

Medical Disclaimer: This post is written for informational purposes only. A part of this post discusses some medicine used to treat cholinergic urticaria which only your doctor has the authority to prescribe. Please, before you take any medication, talk to your healthcare supervisor.

Cholinergic urticaria is one of the physical types of urticaria brought on by a physical stimulus. It is clinically characterized by pinpoint-sized, highly pruritic wheals. However, the symptoms diminish quickly, usually within one hour.

Cholinergic urticaria affects both men and women alike, and unlike all the other types of hives, cholinergic urticaria seems to be more common in men than in women.

In comparison to other chronic urticaria types, cholinergic is uncommon and constitutes 5.1% of all chronic urticaria diagnoses.


What causes Cholinergic Urticaria?

CU is typically provoked by stimulation such as heat, prolonged exposure to sun, and emotional stress, which elevates the body’s core temperature and promotes sweating. Although warmth, sunlight or exercise can induce cholinergic urticaria, the actual cause is sweating.


Here is a picture explaining scientifically how cholinergic urticaria occurs.

Don’t worry, in the next few moments we’ll demystify the puzzle. By understanding how cholinergic urticaria is caused, you will understand what can be done to easily get rid of it. Sound fair enough?

There are two types of causes of cholinergic urticaria – one can be called “direct” and the second can be called “peripheral”. The direct cause is sweating hypersensitivity. The peripheral cause takes a longer cycle to end up releasing histamine, which Yassin Madwin mentioned in his book.  The fact of the matter is that this “indirect” cause is another type of urticaria. In this post I’m going to focus on the direct cause: sweating hypersensitivity.


You are aware that your sweat, your hormones, whatever is inside you is there to do a certain job, and that job does not include breaking you out in hives. Thus, you must be doing something wrong, right?

What causes cholinergic urticaria is the stimulation of a chemical called acetylcholine. Acetylcholine is proven to induce both sweating and wheals when injected underneath your skin. And you wouldn’t believe why you break out in cholinergic urticaria: it’s simply because you eat too much salt. Yes, that is the actual cause of your mysterious hives.


Table salt or any other food rich in sodium can trigger and aggravate your cholinergic urticaria. Sodium stimulates acetylcholine release. You can see how this mechanism works here.


How to treat Cholinergic Urticaria.

Cholinergic urticaria can be treated permanently by avoiding salt and sodium-rich foods in general.

Canned foods, sauces, French fries, soup packets – all of these contain way more than the amount of sodium your body needs, which is set at 1500 mg/day.

Reducing or avoiding those types of food is for the long term. Quick treatments for cholinergic urticaria include: Nonsedating H1 receptor antagonists, such as Cetirizine, Danazol,  and beta-blockers, such as Propranolol.

Your doctor may prescribe medication:

  • 4 mg of chlorpheniramine maleate (histidine), 3 times daily.
  • 200 mg of cimetidine (tagadine), 3 times daily.


Antihistamines won’t do much because histamine plays a very minor role in cholinergic urticaria.

The most effective treatment for cholinergic urticaria according to Yassin Madwin is through desensitization using partially purified sweat antigen. You can call it diluting your sweat. This technique succeeded in 5 out of 6 patients (83%). Note that and give it to your dermatologist – he will know what to do next.

Urticaria no more is not a complicated scientific book, but rather a simple and to the point blueprint anyone can follow. In this book you’re going to discover the one link between all types of urticaria, how you can easily get rid of chronic idiopathic urticaria, how hives during pregnancy and menstruation can be very serious, and much more….

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